フッ素についてのまとめです。
一旦リンクだけ貼っておきます。
The Many Roles for Fluorine in Medicinal Chemistry
https://pubs.acs.org/doi/abs/10.1021/jm800219f
Fluorination Patterning: A Study of Structural Motifs That Impact Physicochemical Properties of Relevance to Drug Discovery
https://pubs.acs.org/doi/abs/10.1021/acs.jmedchem.5b01455
Fluorine in Medicinal Chemistry
https://onlinelibrary.wiley.com/doi/full/10.1002/cbic.200301023
Fluorine as a Hydrogen‐Bond Acceptor: Experimental Evidence and Computational Calculations
https://onlinelibrary.wiley.com/doi/full/10.1002/chem.201402858
Applications of Fluorine in Medicinal Chemistry
https://pubs.acs.org/doi/abs/10.1021/acs.jmedchem.5b00258
Fluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug Design
https://pubs.acs.org/doi/10.1021/acs.jmedchem.7b01788
Quantitative Assessment of the Impact of Fluorine Substitution on P-Glycoprotein (P-gp) Mediated Efflux, Permeability, Lipophilicity, and Metabolic Stability
https://pubs.acs.org/doi/abs/10.1021/acs.jmedchem.6b00027