フッ素

フッ素についてのまとめです。

一旦リンクだけ貼っておきます。

The Many Roles for Fluorine in Medicinal Chemistry

https://pubs.acs.org/doi/abs/10.1021/jm800219f

Fluorination Patterning: A Study of Structural Motifs That Impact Physicochemical Properties of Relevance to Drug Discovery

https://pubs.acs.org/doi/abs/10.1021/acs.jmedchem.5b01455

Fluorine in Medicinal Chemistry

https://onlinelibrary.wiley.com/doi/full/10.1002/cbic.200301023

Fluorine as a Hydrogen‐Bond Acceptor: Experimental Evidence and Computational Calculations

https://onlinelibrary.wiley.com/doi/full/10.1002/chem.201402858

Applications of Fluorine in Medicinal Chemistry

https://pubs.acs.org/doi/abs/10.1021/acs.jmedchem.5b00258

Fluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug Design

https://pubs.acs.org/doi/10.1021/acs.jmedchem.7b01788

Quantitative Assessment of the Impact of Fluorine Substitution on P-Glycoprotein (P-gp) Mediated Efflux, Permeability, Lipophilicity, and Metabolic Stability

https://pubs.acs.org/doi/abs/10.1021/acs.jmedchem.6b00027